CHIR99021 (hydrochloride), CAS 1797989-42-4

CHIR99021 (hydrochloride), CAS 1797989-42-4
Artikelnummer
CAY39176-1
Verpackungseinheit
1 mg
Hersteller
Cayman Chemical

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Formulation: A solid

Formal Name: 6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile, monohydrochloride

Purity: ≥95%

Formula Markup: C22H18Cl2N8 • HCl

Formula Weight: 501,8

Shelf life (days): 730

CAS Number: 1797989-42-4

Notes: CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.{19045} When tested against twenty different protein kinases, this inhibitor shows greater than 500-fold selectivity for GSK3. CHIR99021 activates glycogen synthesis in CHO-IR cells (EC50 = 0.763 μM) and in isolated type 1 diabetic rat skeletal muscle. A single oral dose (30 mg/kg) of CHIR99021 enhances in vivo glucose metabolism in a rodent model of type 2 diabetes. CHIR99021 has also been shown to induce the reprogramming of murine and human somatic cells into stem cells.{19047,16878}
Mehr Informationen
Artikelnummer CAY39176-1
Hersteller Cayman Chemical
Hersteller Artikelnummer 39176-1
Green Labware Nein
Verpackungseinheit 1 mg
Mengeneinheit STK
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