COH000, CAS 1534358-79-6

Formulation: A solid

Formal Name: (1R,4S)-1-[(1R)-2-(4-methylphenyl)-1-(phenylamino)ethyl]-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylic acid, 2,3-dimethyl ester

Purity: ≥98%

Formula Markup: C25H25NO5

Formula Weight: 419,5

Shelf life (days): 1460

CAS Number: 1534358-79-6

Notes: COH000 is an inhibitor of SUMO-activating enzyme (SAE; IC50 = 0.2 µM), a heterodimer composed of SAE1 and SAE2.{58874} It is selective for SAE over ubiquitin-activating enzyme (UAE) and NEDD8-activating enzyme (NAE) at 10 µM. COH000 induces degradation of SAE2 in HCT116 human colon cancer cells. COH000 (10 mg/kg) induces intratumoral apoptosis, decreases intratumoral c-Myc expression, and reduces tumor growth in an HCT116 mouse xenograft model.

• Artikelnummer: CAY34906-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 34906-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK
• Methode: Reinstoffe