Cudetaxestat, CAS 1782070-21-6

Formulation: A solid

Formal Name: 3-[[2,6-dichloro-7-fluoro-1-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-yl]thio]-2-fluoro-benzoic acid

Purity: ≥98%

Formula Markup: C21H15Cl2F2N3O2S

Formula Weight: 482,3

Shelf life (days): 1460

CAS Number: 1782070-21-6

Notes: Cudetaxestat is an inhibitor of autotaxin (IC50 = ≤0.5 µM), also known as ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2).{68483,68484} It reduces migration of MDA-MB-435 melanoma cells (IC50 = 15 nM).{68484} Cudetaxestat reduces blood glucose levels in a glucose tolerance test, as well as baseline blood glucose levels, in mice fed a high-fat diet when administered at a dose of 15 mg/kg twice per day for two days.{68483} It reduces liver fibrosis in mice fed a choline-deficient, L-amino acid-defined, high-fat diet (CDAA/HFD) as a model of liver fibrosis when administered at a dose of 10 mg/kg.{68484} It also reduces colon ulcer area and increases colon length in mouse models of acute and chronic ulcerative colitis, respectively.

• Artikelnummer: CAY38789-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38789-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK