δ-Secretase Inhibitor 11, CAS 842964-18-5

Formulation: A solid

Formal Name: 7-(4-morpholinyl)-2,1,3-benzoxadiazol-4-amine

Purity: ≥95%

Formula Markup: C10H12N4O2

Formula Weight: 220,2

Shelf life (days): 1460

CAS Number: 842964-18-5

Notes: δ-Secretase inhibitor 11 is an inhibitor of δ-secretase (IC50 = 0.7 µM), also known as asparagine endopeptidase (AEP) and legumain.{65769} It is selective for δ-secretase over cathepsin S, cathepsin L, caspase-3, and caspase-8 (IC50s = >200, >200, 31.86, and 86.71 µM, respectively). δ-Secretase inhibitor 11 inhibits δ-secretase in Pala B-lymphoblastoid cells (IC50 = 0.8 µM). It inhibits glucose-oxygen deprivation-induced cell death in primary mouse neurons when used at a concentration of 2 µM. In vivo, δ-secretase inhibitor 11 (10 mg/kg per day) inhibits brain δ-secretase in wild-type mice and transgenic mice expressing human tauP301S. It reduces the number of cortical and hippocampal tau N368-positive neurons, restores synaptic dysfunction, and improves spatial learning and memory in transgenic mice expressing human tauP301S. δ-Secretase inhibitor 11 (10 mg/kg) reduces hippocampal amyloid-β (Aβ) deposition and attenuates cognitive deficits in the 5XFAD transgenic mouse model of Alzheimer’s disease.

• Artikelnummer: CAY38524-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38524-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK