DKM 2-93, CAS 65836-72-8

Formulation: A crystalline solid

Formal Name: 2-chloro-N-[(3,4-dimethoxyphenyl)methyl]-acetamide

Purity: ≥98%

Formula Markup: C11H14ClNO3

Formula Weight: 243,7

Shelf life (days): 1460

CAS Number: 65836-72-8

Notes: DKM 2-93 is a cysteine-reactive covalent inhibitor of ubiquitin-like modifier activating enzyme 5 (UBA5; IC50 = 450 µM).{69492} It decreases survival of PaCa-2 pancreatic cancer cells without affecting human pancreatic ductal epithelial cells (HPDEs) when used at a concentration of 50 µM. In vivo, DKM 2-93 (50 mg/kg per day) reduces tumor volume without reducing body weight in a PaCa-2 pancreatic cancer mouse xenograft model. It has also been used as an intermediate in the synthesis of topoisomerase I inhibitors and compounds active against M. tuberculosis.{69493,69494}

• Artikelnummer: CAY37293-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37293-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK