DL-threo-β-Hydroxyaspartic Acid, CAS 4294-45-5

Formulation: A solid

Formal Name: rel-3R-hydroxy-D-aspartic acid

Purity: ≥95%

Formula Markup: C4H7NO5

Formula Weight: 149,1

Shelf life (days): 1460

CAS Number: 4294-45-5

Notes: DL-threo-β-Hydroxyaspartic acid is an inhibitor of excitatory amino acid transporters (EAATs).{45698,45699} It inhibits glutamate uptake in COS-1 cells expressing human EAAT1 or EAAT2 (IC50s = 96 and 31 µM, respectively) as well as inward currents induced by L-aspartate in EAAT4-expressing Xenopus oocytes (Ki = 0.6 µM) and by L-glutamate in EAAT5-expressing oocytes (Ki = 2.5 µM) voltage-clamped at -60 mV. Intrathecal administration of DL-threo-β-hydroxyaspartic acid (7.5 and 15 µg/animal) reduces the number of flinches and shakes in the second phase of the formalin test in rats.{45701}

• Artikelnummer: CAY35274-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35274-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK
• Methode: Reinstoffe