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Doramapimod , CAS 285983-48-4
Doramapimod , CAS 285983-48-4
Artikelnummer
BPS27034
Verpackungseinheit
25 mg
Hersteller
BPS Bioscience
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CAS Number: 285983-48-4
Description: Doramapimod is a protein kinase inhibitor with a >330-fold selectivity for p38 MAPK compared with 12 other protein kinases. Doramapimod prevents both the kinetic activity and phosphorylation of p38 MAPK by binding to the ATP pocket as well as to a novel allosteric binding site on p38 MAPK. Doramapimod also blocks proliferation of cells expressing BCR-ABL(T315I), with an IC50 of 2-3 µM.
Format: White to off-white solid.
Purity: ≥98%
Solubility: Soluble in DMSO at 50 mg/ml; soluble in ethanol at 30 mg/ml; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-20 µM
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Branger, J., et al. J. Immunol. 168: 4070-4077 (2002).
2. Carter, T.A., et al. Proc. Natl. Acad. Sci. USA 102: 11011-11016 (2005).
CAS Number: 285983-48-4
Description: Doramapimod is a protein kinase inhibitor with a >330-fold selectivity for p38 MAPK compared with 12 other protein kinases. Doramapimod prevents both the kinetic activity and phosphorylation of p38 MAPK by binding to the ATP pocket as well as to a novel allosteric binding site on p38 MAPK. Doramapimod also blocks proliferation of cells expressing BCR-ABL(T315I), with an IC50 of 2-3 µM.
Format: White to off-white solid.
Purity: ≥98%
Solubility: Soluble in DMSO at 50 mg/ml; soluble in ethanol at 30 mg/ml; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-20 µM
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Branger, J., et al. J. Immunol. 168: 4070-4077 (2002).
2. Carter, T.A., et al. Proc. Natl. Acad. Sci. USA 102: 11011-11016 (2005).
| Artikelnummer | BPS27034 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 27034 |
| Green Labware | Nein |
| Verpackungseinheit | 25 mg |
| Mengeneinheit | STK |
| Produktinformation (PDF) |
|
| MSDS (PDF) |
|
Immer für Sie da
Gernot Ensinger, M.Sc.
Laurent Haze
