Dorzolamide (hydrochloride), CAS 130693-82-2

Formulation: A crystalline solid

Formal Name: (4S,6S)-4-(ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide, 7,7-dioxide, monohydrochloride

Purity: ≥98%

Formula Markup: C10H16N2O4S3 • HCl

Formula Weight: 360,9

Shelf life (days): 1460

CAS Number: 130693-82-2

Notes: Dorzolamide is an inhibitor of carbonic anhydrase (CA), inhibiting CAII, CAV, CAVI, CAIX, CAXII, CAXIII, and CAXIV with Ki values ranging from 3.5 to 52 nM.{23433,23435,23434} It is selective for these isoforms over CAI, CAIII, and CAIV (Kis = 50, 8, and 8.5 μM, respectively).{23433} Dorzolamide inhibits carbonic anhydrase in isolated rabbit iris-ciliary body by 87% when used at a concentration of 0.02%.{23434} It also reduces intraocular pressure in an α-chymotrypsin-treated rabbit model of ocular hypertension and in normotensive rabbits when applied topically at a concentration of 0.5%.{23434} Formulations containing dorzolamide have been used in the treatment of glaucoma.{23432,23436}

• Artikelnummer: CAY14616-250
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 14616-250
• Green Labware: Nein
• Verpackungseinheit: 250 mg
• Mengeneinheit: STK