(E/Z)-IT-603, CAS 292168-90-2

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 5-[(5-bromo-2-hydroxy-3-methoxyphenyl)methylene]-2-thioxo-4-imidazolidinone

Purity: ≥98%

Formula Markup: C11H9BrN2O3S

Formula Weight: 329.17084

CAS Number: 292168-90-2

Notes: (E/Z)-IT-603 is a mixture of (E)-IT-603 and (Z)-IT-603.{72125} (Z)-IT-603 is a c-Rel inhibitor (IC50 = 3 µM). (Z)-IT-603 inhibits c-Rel DNA binding in an electrophoretic mobility-shift assay (EMSA). Preincubation of (Z)-IT-603 (20 µM) with mouse T cells prevents the development of graft-versus-host disease (GVHD) but does not affect graft-versus-tumor (GVT) activity in a mouse model of allogeneic hematopoietic stem cell transplantation.

• Artikelnummer: CAY37792-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37792-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK