Emvododstat, CAS 1256565-36-2

Formulation: A solid

Formal Name: (1S)-6-chloro-1,3,4,9-tetrahydro-1-(4-methoxyphenyl)-2H-pyrido[3,4-b]indole-2-carboxylic acid, 4-chlorophenyl ester

Purity: ≥98%

Formula Markup: C25H20Cl2N2O3

Formula Weight: 467,3

Shelf life (days): 1460

CAS Number: 1256565-36-2

Notes: Emvododstat is an inhibitor of dihydroorotate dehydrogenase (DHODH).{68172} It inhibits DHODH by 89% in HeLa cells when used at a concentration of 100 nM. Emvododstat inhibits hypoxia-induced VEGF-A synthesis in HeLa cells (EC50 = 1.64 nM). It inhibits viral replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), hepatitis C virus (HCV) replicon genotype 1b, poliomyelitis virus, Rift Valley fever (RVF) virus, and Ebola virus in Vero, Huh7, HeLa, HeLa, and Vero 76 cells, respectively (EC50s = 2.6, 36, 0.57, 13, and 9.1 nM, respectively).{68173} Emvododstat inhibits production of IL-17F and IL-17A induced by CD3 and CD28 in Th17 cells in a concentration-dependent manner.

• Artikelnummer: CAY36877-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36877-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe