ENPP1 Inhibitor 4e

Formulation: A solid

Formal Name: 7-fluoro-2-(((5-methoxy-1H-imidazo[4,5-b]pyridin-2-yl)thio)methyl)quinazolin-4(3H)-one

Purity: ≥98%

Formula Markup: C16H12FN5O2S

Formula Weight: 357,4

Shelf life (days): 730

Notes: ENPP1 inhibitor 4e is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1; IC50 = 0.188 µM), an enzyme that degrades the stimulator of interferon genes (STING) activator 2'3'-cGAMP (Item No. 19887).{69139} It inhibits ENPP1 in MDA-MB-231 cells, which highly express ENPP1 (IC50 = 0.732 µM). ENPP1 inhibitor 4e is selectively cytotoxic to 4T1 murine metastatic breast cancer cells (IC50 = 2.99 µM) over non-cancerous L-02 and 293T cells at 50 µM. It increases serum levels of IFN-β in mice when administered at a dose of 0.5 mg/kg in combination with cGAMP when compared to mice administered only cGAMP or mice not receiving either compound, indicating that ENPP1 inhibitor 4e reduces the degradation of cGAMP.

• Artikelnummer: CAY37687-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37687-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK
• Methode: Reinstoffe