Entecavir, CAS 142217-69-4

Formulation: A solid

Formal Name: 2-amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one

Purity: ≥98%

Formula Markup: C12H15N5O3

Formula Weight: 277,3

Shelf life (days): 1460

CAS Number: 142217-69-4

Notes: Entecavir is an antiviral nucleoside analog of 2'-deoxyguanosine (Item No. 9002864) and inhibitor of hepatitis B virus (HBV) reverse transcriptase (IC50 = 0.5 nM).{22164,59703} It undergoes phosphorylation by cellular kinases to its active form, entecavir triphosphate.{53861,59703} Entecavir reduces virion DNA in the culture supernatant of HepG2 2.2.15 cells infected with hepatitis B virus (HBV; EC50 = 3.75 nM).{22164} It reduces serum and hepatic levels of viral DNA in a duckling model of HBV infection when administered at a dose of 1 mg/kg.{22166} Formulations containing entecavir have been used in the treatment of chronic HBV infection.

• Artikelnummer: CAY36926-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36926-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe