Formulation: A solid
Formal Name: N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, monohydrochloride
Purity: ≥98%
Formula Markup: C22H23N3O4 • HCl
Formula Weight: 429,9
Shelf life (days): 1460
CAS Number: 183319-69-9
Notes: Erlotinib is an EGFR inhibitor (Ki = 2.7 nM).{18353} It is greater than 1,000-fold selective for EGFR over Src and Abl at 0.1 µM.{69208} Erlotinib induces caspase-3 and -7 activity in NCI H358 non-small cell lung cancer (NSCLC) cells when used at a concentration of 1 µM.{18351} Erlotinib (25 mg/kg) reduces EGF-induced EGFR autophosphorylation in an HN-5 head and neck cancer mouse xenograft model.{69208} Formulations containing erlotinib have been used in the treatment of various cancers.