FK-866, CAS 658084-64-1

Formulation: A crystalline solid

Formal Name: N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide

Purity: ≥98%

Formula Markup: C24H29N3O2

Formula Weight: 391,5

Shelf life (days): 730

CAS Number: 658084-64-1

Notes: FK-866 is a highly specific non-competitive inhibitor of Nampt (Ki = 0.4 nM), causing gradual NAD+ depletion.{17256} In HepG2 human liver carcinoma cells, NAD+ depletion by FK-866 directs delayed cell death by apoptosis (IC50 = ~1 nM).{17256} In normal human smooth muscle cells, FK-866 causes premature senescence, an effect that may be linked to decreased activity of the NAD+-dependent enzyme SIRT1.{17254} Also, FK-866 induces autophagy in SH-SY5Y neuroblastoma cells, as indicated by the formation of LC3-positive vesicles.{17255}

• Artikelnummer: CAY13287-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 13287-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK