Flavokawain 1i, CAS 1098176-51-2

Formulation: A solid

Formal Name: (2E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(1-naphthalenyl)-2-propen-1-one

Purity: ≥98%

Formula Markup: C21H18O4

Formula Weight: 334,4

Shelf life (days): 1460

CAS Number: 1098176-51-2

Notes: Flavokawain 1i is a derivative of the chalcones flavokawain A (Item No. 36083), flavokawain B (Item No. 19652), and flavokawain C (Item No. 39393) and has anticancer and antiviral activities.{51412,51413} It inhibits the proliferation of gefitinib-resistant H1975 non-small cell lung cancer (NSCLC) cells by 36%, as well as decreases protein levels of the heat shock protein 90 (Hsp90) client proteins EGFR, c-Met, HER2, Akt, and cyclin-dependent kinase 4 (Cdk4) and increases protein levels of Hsp70, markers of Hsp90 inhibition, when used at a concentration of 30 µM.{51412} Intramuscular administration of flavokawain 1i reduces viral titers in pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV).{51413}

• Artikelnummer: CAY39394-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39394-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK