Fulacimstat, CAS 1488354-15-9

Formulation: A solid

Formal Name: 1-(2,3-dihydro-3-methyl-2-oxo-6-benzoxazolyl)-3-[(1R)-2,3-dihydro-4-(trifluoromethyl)-1H-inden-1-yl]-1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinecarboxylic acid

Purity: ≥98%

Formula Markup: C23H16F3N3O6

Formula Weight: 487,4

Shelf life (days): 1460

CAS Number: 1488354-15-9

Notes: Fulacimstat is an inhibitor of chymase (IC50s = 4 and 3 nM for the human and hamster enzyme, respectively).{66530} It reduces cardiac fibrosis induced by the β1-adrenergic receptor (B1-AR) and β2-AR agonist isoprenaline (isoproterenol; Item No. 15592) in hamsters when administered at doses of 1, 3, and 10 mg/kg. Fulacimstat (2 and 5 mg/kg per day) inhibits microembolism-induced decreases in left ventricular ejection fraction and increases in left ventricular end-systolic volume, decreases in plasma levels of N-terminal pro-brain natriuretic peptide (nt-proBNP), TGF-β1, and TNF-α, as well as the levels of interstitial fibrosis and the cross-sectional area of myocytes, a measure of myocyte hypertrophy, in a coronary microembolism-induced canine model of heart failure.{66531}

• Artikelnummer: CAY37731-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37731-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK