Formulation: A solid
Formal Name: 2,6-dichloro-N-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-benzamide
Purity: ≥98%
Formula Markup: C16H13Cl2N3O2
Formula Weight: 350,2
Shelf life (days): 1460
CAS Number: 1258292-64-6
Notes: GDC-046 is a tyrosine kinase 2 (TYK2) inhibitor (Ki = 4.8 nM).{68143} It is selective for TYK2 over JAK1, -2, and -3 (Kis = 83.8, 27.6, and 253 nM, respectively). GDC-046 selectively inhibits TYK2-mediated IL-12-induced phosphorylation of STAT4 over JAK1-mediated IL-6-induced phosphorylation of STAT3 and JAK2-mediated erythropoietin-induced phosphorylation of STAT5 in cell-based assays (EC50s = 380, 2,000, and 1,700 nM, respectively).