Gingerenone A, CAS 128700-97-0

Formulation: A solution in ethanol

Formal Name: 1,7-bis(4E-hydroxy-3-methoxyphenyl)-4-hepten-3-one

Purity: ≥98%

Formula Markup: C21H24O5

Formula Weight: 356,4

Shelf life (days): 730

CAS Number: 128700-97-0

Notes: Gingerenone A is a diarylheptanoid and polyphenol that has been found in Z. officinale and has diverse biological activities.{62845,62846,62847,62848,62849} It inhibits tyrosinase (IC50 = 9.4 µM for the mushroom enzyme) and scavenges DPPH (Item No. 14805) radicals in a cell-free assay (IC50 = 12.6 µM).{62845,62846} Gingerenone A (5 and 10 µM) also inhibits JAK2 and p70 ribosomal S6 kinase 1 (p70S6K1).{62847} It selectively decreases the viability of ionizing radiation-induced senescent WI38 fibroblasts over proliferating fibroblasts when used at a concentration of 20 µM.{62848} Gingerenone A (50 mg/kg) prevents increases in body weight but does not affect caloric intake in a mouse model of high-fat diet-induced obesity.{62849} It decreases tumor weight in an HCT116 colon cancer mouse xenograft model when administered at doses of 5 and 20 mg/kg.{62847}

• Artikelnummer: CAY36841-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36841-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK
• Methode: Reinstoffe