GSK256066 , CAS 801312-28-7

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Biological Activity: IC50 =3.2 pM for PDE4B, with >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7. GSK256066 inhibits PDE4 isoforms A-D with equal affinity.

CAS Number: 801312-28-7

Description: GSK256066 is a selective PDE4 inhibitor with an exceptionally high-affinity and selective inhibitor of phosphodiesterase 4 vs. other PDE isoforms. Often used clinically by inhalation in chronic obstructive pulmonary disease and asthma.

Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Target: PDE4

Biosafety Level: Not applicable (BSL-1)

References: 1. Tralau-Stewart CJ, et al. J Pharmacol Exp Ther, 2011, 337(1), 145-154.
2. Woodrow MD, et al. Bioorg Med Chem Lett, 2009, 19(17), 5261-5265.

• Artikelnummer: BPS27751-1
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 27751-1
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK