Harmalol (hydrochloride hydrate), CAS 6028-00-8

Formulation: A solid

Formal Name: 4,9-dihydro-1-methyl-3H-pyrido[3,4-b]indol-7-ol, monohydrochloride, dihydrate

Purity: ≥98%

Formula Markup: C12H12N2O • HCl [2H2O]

Formula Weight: 272,7

Shelf life (days): 1460

CAS Number: 6028-00-8

Notes: Harmalol is a β-carboline alkaloid and an active metabolite of harmaline that has been found in P. harmala and has diverse biological activities.{61772,64513,65022,64514,64515} It is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A; IC50 = 0.63 µM) and monoamine oxidase A (MAO-A; IC50 = 0.66 µM).{65022} It is selective for DYRK1A over Cdk1, Cdk5, CK1α1, Clk4, DYRK2, Pim-1, and GSK3β but also inhibits DYRK1B and Clk1 at 10 µM. It inhibits proliferation of H4 human glioblastoma cells (IC50s = 23.7 µM). Harmalol (0.5-12.5 µM) reduces increases in the levels of the cytochrome P450 (CYP) isoform CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells and prevents TCDD-induced activation of the aryl hydrocarbon receptor (AhR) in guinea pig hepatic cytosolic extracts.{64514} It reduces glutamate-induced cytotoxicity, cytochrome c release, caspase-3 activation, and the production of reactive oxygen species (ROS) in PC12 cells when used at a concentration of 25 µM.{64515} This product is also available as an analytical reference standard (Item No. 35145).

• Artikelnummer: CAY36090-250
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36090-250
• Green Labware: Nein
• Verpackungseinheit: 250 mg
• Mengeneinheit: STK
• Methode: Reinstoffe