I-BET151, CAS 1300031-49-5

Formulation: A crystalline solid

Formal Name: 7,3,5-dimethyl-4-isoxazolyl-1,3-dihydro-8-methoxy-1-[1R-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one

Purity: ≥98%

Formula Markup: C23H21N5O3

Formula Weight: 415,5

Shelf life (days): 1460

CAS Number: 1300031-49-5

Notes: The bromodomain and extra terminal domain (BET) family of proteins including BRD2, BRD3, and BRD4 play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interaction by controlling the assembly of histone acetylation-dependent chromatin complexes.{26201} I-BET151 is an isoxazole class pan-BET family inhibitor, blocking BRD2, BRD3, and BRD4 with IC50 values of 0.5, 0.25, and 0.79 µM, respectively.{20183,25295,22883,28490} Through this action, it blocks the growth of leukemic cell lines driven by mixed lineage leukemia (MLL) fusions at nanomolar concentrations, whereas tyrosine kinase activated cells were much less sensitive.{20182} Specifically, I-BET151 induces apoptosis via reduced expression of BCL2 or triggers G0/G1 cell cycle arrest in MLL-fusion cell lines.{20182} I-BET151 is effective in vivo, suppressing MLL leukemia progression in two different mouse models.{20182}

• Artikelnummer: CAY11181-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 11181-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK