Icariin , CAS 489-32-7

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Biological Activity: Icariin inhibits human recombinant PDE5 with an IC50 value of 5.9 µM.

CAS Number: 489-32-7

Description: Icariin is a PDE5 inhibitor. It is the active component of the Chinese medicinal plant E. brevicornum. It can induce differentiation of cardiomyocytes and upregulates the expression of cardiac genes. Icariin increase the proliferation and differentiation of cultured human osteoblasts, which appears to be mediated in part by upregulating bone morphogenetic protein 2 mRNA.

Format: A crystalline solid

Purity: ≥97% by HPLC

Solubility: Soluble in DMSO and DMF, purged with an inert gas. Solubility in DMSO and DMFis ~20 mg/ml. For maximum solubility, dissolve in DMSO and then dilute with the aqueousbuffer of choice.

Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Biosafety Level: Not applicable (BSL-1)

References: 1. Dell'Agli, M, et al., J. Nat. Prod. 2008;71(9):1513-1517.
2. Chen, Y., et al., Pharm Res. 2008;25(9):2190-2199.
3. Ding, L., et al., Acta Pharmacol Sin. 2007;28(10):1541-1549.
4. Yin, X., et al., Chin Med J. 2007;120(3):204-210.

• Artikelnummer: BPS27217
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 27217
• Green Labware: Nein
• Verpackungseinheit: 1 g
• Mengeneinheit: STK