icFSP1 (trifluoroacetate salt)

Formulation: A solid

Formal Name: 3,4,5-trimethoxy-N-[4-(2-methyl-4-oxo-3(4H)-quinazolinyl)phenyl]-benzeneacetamide, trifluoroacetate salt

Purity: ≥98%

Formula Markup: C26H25N3O5 • CF3COOH

Formula Weight: 573,5

Shelf life (days): 1095

Notes: icFSP1 is an inhibitor of ferroptosis suppressor protein 1 (FSP1).{65744} It induces condensation and phase separation of FSP1 in cells when used at a concentration of 2.5 µM but does not inhibit FSP1 enzymatic activity in a cell-free assay (IC50 = > 30 µM). icFSP1 induces ferroptosis in HT-1080 fibrosarcoma cells in a concentration-dependent manner. In vivo, icFSP1 (50 mg/kg) decreases tumor volume and weight in a B16/F10 murine melanoma model using human FSP1-overexpressing, Gpx4-/-Fsp1-/- B16/F10 cells.

• Artikelnummer: CAY39347-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39347-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK