ICG 1 , CAS 847591-62-2

Products from BPS Bioscience require a minimum order value above 400€

Background: ICG001 selectively inhibits colon carcinoma cell lines (SW480 and HCT-116 cells) but not normal colonic epithelial cells (CCD-841Co). It is also efficacious in the Min mouse and nude mouse xenograft models of colon cancer. ICG-001 is a potent inhibitor of GBM stem cells in culture. ICG001 selectively inhibits Wnt/beta-catenin/CREB binding protein (CBP) signaling to reverses pulmonary fibrosis and ameliorate experimental dermal fibrosis in experimental models. ICG001 is currently in clinical trials for colon cancer and leukemias.

CAS Number: 847591-62-2

Description: CG001 is a small molecule inhibitor that targets Wnt/β-catenin pathway. It inhibits TCF/β-catenin mediated transcription by competing with β-catenin for CBP (CREB binding protein) but not p300 binding with an IC50 of 3 µM. It can be used to specifically evaluate the role of CBP/beta-catenin association on WNT signaling and cell physiology.

Solubility: Soluble in DMSO

Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Biosafety Level: Not applicable (BSL-1)

References: 1. Emami KH, et al. Proc. Natl. Acad. Sci. USA 2004 Aug 24;101(34):12682-7.
2. Henderson WR Jr., et al. Proc. Natl. Acad. Sci. USA 2010 Aug 10;107(32):14309-14.
3. Beyer C, et al. Ann Rheum Dis. 2013 Jul;72(7):1255-8.

• Artikelnummer: BPS27752-3
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 27752-3
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK