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IWP-L6 , CAS 1427782-89-5
IWP-L6 , CAS 1427782-89-5
Artikelnummer
BPS27755-2
Verpackungseinheit
50 mg
Hersteller
BPS Bioscience
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Background: WP-L6 was developed as a sub-nanomolar inhibitor of Porcupine, the enzyme that catalyzes the palmitoylation of Wnt proteins. In HEK293 cells, IWP-L6 is found to significantly inhibit the phosphorylation of dishevelled 2 (Dvl2). IWP-L6 has good stability in human plasma but weaker stability in rat and mouse plasma. In vivo assay shows that IWP-L6 is quite active in zebrafish. It blocks the regeneration of the tailfin effectively. It also shows inhibition of posterior axis formation at low micromolar concentrations. Additionally, in cultured mouse embryonic kidneys, 10 nM IWP-L6 can significantly reduce branching morphogenesis while 50 nM IWP-L6 completely blocks Wnt signaling.
CAS Number: 1427782-89-5
Description: IWP-L6 is an inhibitor of Porcupine with IC50 value of 0.5 nM.
Solubility: Soluble in DMSO
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Target: Porcupine
Biosafety Level: Not applicable (BSL-1)
References: Wang X, et al. J Med Chem. 2013 Mar 28;56(6):2700-4.
Background: WP-L6 was developed as a sub-nanomolar inhibitor of Porcupine, the enzyme that catalyzes the palmitoylation of Wnt proteins. In HEK293 cells, IWP-L6 is found to significantly inhibit the phosphorylation of dishevelled 2 (Dvl2). IWP-L6 has good stability in human plasma but weaker stability in rat and mouse plasma. In vivo assay shows that IWP-L6 is quite active in zebrafish. It blocks the regeneration of the tailfin effectively. It also shows inhibition of posterior axis formation at low micromolar concentrations. Additionally, in cultured mouse embryonic kidneys, 10 nM IWP-L6 can significantly reduce branching morphogenesis while 50 nM IWP-L6 completely blocks Wnt signaling.
CAS Number: 1427782-89-5
Description: IWP-L6 is an inhibitor of Porcupine with IC50 value of 0.5 nM.
Solubility: Soluble in DMSO
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Target: Porcupine
Biosafety Level: Not applicable (BSL-1)
References: Wang X, et al. J Med Chem. 2013 Mar 28;56(6):2700-4.
| Artikelnummer | BPS27755-2 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 27755-2 |
| Green Labware | Nein |
| Verpackungseinheit | 50 mg |
| Mengeneinheit | STK |
| Produktinformation (PDF) |
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| MSDS (PDF) |
|
Immer für Sie da
Gernot Ensinger, M.Sc.
Laurent Haze
