IXA4, CAS 1185329-96-7

Formulation: A solid

Formal Name: N-methyl-N-[2-(4-methylphenoxy)ethyl]-4-[(1-oxo-3-phenoxypropyl)amino]-1H-pyrazole-1-acetamide

Purity: ≥98%

Formula Markup: C24H28N4O4

Formula Weight: 436,5

Shelf life (days): 1460

CAS Number: 1185329-96-7

Notes: IXA4 is an activator of inositol-requiring enzyme 1 (IRE1).{69114} It induces the expression of the Ire1 target Xpb1s in primary mouse hepatocytes. In vivo, IXA4 (50 mg/kg) decreases hepatic expression of the Xbp1 target gene Dnajb9 in wild-type mice and a mouse model of high-fat diet-induced obesity, effects that can be reversed by the IRE1 inhibitor STF-083010 (Item No. 17370). IXA4 also increases glucose tolerance and suppresses hepatic gluconeogenesis and steatosis in a mouse model of high-fat diet-induced obesity.

• Artikelnummer: CAY36788-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36788-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK
• Methode: Reinstoffe