JPH203 (hydrochloride), CAS 1597402-27-1

Formulation: A solid

Formal Name: O-[(5-amino-2-phenyl-7-benzoxazolyl)methyl]-3,5-dichloro-L-tyrosine, dihydrochloride

Purity: ≥98%

Formula Markup: C23H19Cl2N3O4 • 2HCl

Formula Weight: 545,2

Shelf life (days): 730

CAS Number: 1597402-27-1

Notes: JPH203 is an inhibitor of L-type amino acid transporter 1 (LAT1; IC50 = 0.14 μM for 14C-leucine uptake in S2 cells expressing the human transporter).{52371} It is selective for LAT1 over LAT2 (IC50 = >10 μM). JPH203 inhibits 14C-leucine uptake by, and growth of, HT-29 cells (IC50s = 0.06 and 4.1 μM, respectively). It induces apoptosis and increases levels of cleaved caspase-3, caspase-7, caspase-9, and poly(ADP-ribose) polymerase (PARP) in YD-38 oral cancer cells when used at a concentration of 3 mM.{52372} JPH203 (6.3, 12.5, and 25 mg/kg) reduces tumor growth in an HT-29 mouse xenograft model.{52371}

• Artikelnummer: CAY36053-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36053-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe