(+)-JQ1 , CAS 1268524-70-4

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Biological Activity: (+)-JQ1 has been shown to inhibit BRD4 (BD1) with a Kd of 50 nM, and BRD4 (BD2) with a Kd of 90 nM.

CAS Number: 1268524-70-4

Description: (+)-JQ1 is a specific inhibitor of the BET family of acetyl-lysine recognition motifs, including the BRD2, BRD3, BRD4 and BRDT bromodomains.

Format: A crystalline solid

Purity: ≥95% by HPLC

Solubility: Soluble in DMSO or ethanol; insoluble in water.

Storage Stability: Store at or below +4°C. Stable at least 6 months from date of receipt, when stored as directed.

Biosafety Level: Not applicable (BSL-1)

References: Filippakopoulos P., et al. Nature. 468(7327):1067-73 (2011).Application Reference(s):1.Pinz, S., et al. Nucleic Acids Res. 2015 Apr 20;43(7):3524-45. "Deacetylase inhibitors repress STAT5-mediated transcription by interfering with bromodomain and extra-terminal (BET) protein function"
2. BET bromodomain inhibitors block growth of pancreatic cancer cells in three-dimensional collagen (2014)
3. Dual kinase-bromodomain inhibitors for rationally designed polypharmacology (2014)
4. BET bromodomain protein inhibition is a therapeutic option for medulloblastoma (2013)

• Artikelnummer: BPS27401
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 27401
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK