JZL 184, CAS 1101854-58-3

Formulation: A crystalline solid

Formal Name: 4-nitrophenyl-4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate

Purity: ≥97%

Formula Markup: C27H24N2O9

Formula Weight: 520,5

Shelf life (days): 730

CAS Number: 1101854-58-3

Notes: Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JZL 184 is a potent and selective inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 8 nM and 4 µM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain membranes, respectively.{16639} When administered to mice at 16 mg/kg, intraperitoneally, JZL 184 reduces MAGL activity by 85%, elevates brain 2-AG levels by 8-fold, and elicits analgesic activity in a variety of pain assays that qualitatively mimics direct central cannabinoid (CB1) agonists.{16639}

• Artikelnummer: CAY13158-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 13158-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK