KAS 08, CAS 203861-20-5

Formulation: A solid

Formal Name: (4S)-1-[[2,3-dihydro-1-(4-nitrobenzoyl)-1H-indol-5-yl]sulfonyl]-4-phenyl-2-imidazolidinone

Purity: ≥95%

Formula Markup: C24H20N4O6S

Formula Weight: 492,5

Shelf life (days): 730

CAS Number: 203861-20-5

Notes: KAS 08 is an activator of stimulator of interferon genes (STING).{69166} It activates STING with an EC50 value of 0.33 µM in a reporter assay using THP-1 human monocytes. KAS 08 increases the levels of IFN-β and IP-10 in the presence, but not absence, of cGAMP. It reduces the viability of CT26 mouse colorectal cancer cells when used at concentrations ranging from 0.31 to 20 µM. KAS 08 (15 mg/kg), when administered in combination with exogenous 2’3’-cGAMP (Item No. 19887), reduces tumor growth in a CT26 mouse syngeneic model.

• Artikelnummer: CAY36474-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36474-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe