KIN1148, CAS 1428729-56-9

Formulation: A crystalline solid

Formal Name: N-benzo[1,2-d:3,4-d′]bisthiazol-2-yl-2-naphthalenecarboxamide

Purity: ≥98%

Formula Markup: C19H11N3OS2

Formula Weight: 361,4

Shelf life (days): 1460

CAS Number: 1428729-56-9

Notes: KIN1148 is an IFN regulating factor 3 (IRF3) activator and adjuvant.{65747} It increases the mRNA expression of the genes encoding IFN-stimulated gene 54 (ISG54) and 2'-5'-oligoadenylate synthase-like (OASL) protein in PH5CH8 cells and increases chemokine (C-X-C motif) ligand 10 (CXCL10) production in phorbol 12-myristate 13-acetate-differentiated THP-1 monocytes when used at a concentration of 10 µM. Immunization with a vaccine in combination with KIN1148 as an adjuvant increases blood IgG, neutralizing, and hemagglutinin antibody titers, decreases particle-forming units (PFUs) in the lungs and lung-draining lymph nodes, and increases the survival percentage of mice infected with a lethal dose of influenza virus.

• Artikelnummer: CAY38980-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38980-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK