Liarozole, CAS 115575-11-6

Formulation: A solid

Formal Name: 6-[(3-chlorophenyl)-1H-imidazol-1-ylmethyl]-1H-benzimidazole

Purity: ≥98%

Formula Markup: C17H13ClN4

Formula Weight: 308,8

Shelf life (days): 1460

CAS Number: 115575-11-6

Notes: Liarozole is an inhibitor of the cytochrome P450 (CYP) isoform CYP26A1 (IC50 = 2.1 µM), an enzyme involved in the metabolism of all-trans retinoic acid (Item No. 11017).{58961} It also inhibits the production of estradiol (Item No. 10006315) induced by follicle-stimulating hormone (FSH) in rat granulosa cells and testosterone and androstenedione production induced by human chorionic gonadotropin (hCG) in rat testicular cells (IC50s = 0.4, 2.3, and 0.7 µM, respectively).{58962} Liarozole enhances the antiproliferative activity of all-trans retinoic acid in MCF-7 breast cancer cells.{58963} It decreases plasma levels of retinoic acid in rats in a dose-dependent manner.{58964} Liarozole (5 and 20 mg/kg) decreases estradiol undecylate-induced vaginal keratinization in ovariectomized rats.

• Artikelnummer: CAY29491-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29491-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK
• Methode: Reinstoffe