LM-10, CAS 1316695-35-8

Formulation: A solid

Formal Name: 6-fluoro-3-[(1E)-2-(2H-tetrazol-5-yl)ethenyl]-1H-indole

Purity: ≥98%

Formula Markup: C11H8FN5

Formula Weight: 229,2

Shelf life (days): 1460

CAS Number: 1316695-35-8

Notes: LM-10 is an inhibitor of tryptophan 2,3-dioxygenase (TDO; IC50 = 2 µM).{65521} It is selective for TDO over indoleamine 2,3-dioxygenase (IDO), monoamine oxidase A (MAO-A), and MAO-B, as well as a panel of various receptors and transporters, at 10 µM. LM-10 (1 mg/ml in the drinking water) reverses tumoral immune resistance in a TDO-overexpressing P815B mastocytoma syngeneic model using mice immunized with the P815 antigen P1A.{61677} Oral administration of LM-10 (50 mg/kg) prevents decreases in the number of dopaminergic neurons and increases in microglial cell volume, a marker of neuroinflammation, in the substantia nigra and inhibits decreases in intestinal transit in a mouse model of Parkinson’s disease induced by rotenone (Item No. 13995).{65522}

• Artikelnummer: CAY36291-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36291-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe