LOR253, CAS 916151-99-0

Formulation: A solid

Formal Name: 2-(5-fluoro-2-methyl-1H-indol-3-yl)-1H-imidazo[4,5-f][1,10]phenanthroline

Purity: ≥98%

Formula Markup: C22H14FN5

Formula Weight: 367,4

Shelf life (days): 1460

CAS Number: 916151-99-0

Notes: LOR253 is an activator of the transcription factor Kruppel-like factor 4 (KLF4).{62832} It increases levels of KLF4 and induces apoptosis in HCC1187, HCC38, and MDA-MB-468 cancer cells when used at concentrations of 5 and 10 µM. It is cytotoxic in a panel of 16 acute myeloid leukemia (AML) and lymphoma cell lines (IC50s = 0.057-1.75 µM) and induces cell cycle arrest at the G0/G1 phase in MV4-11, KG-1, and EoL-1 cells.{62833} LOR253 (1 mg/kg) accelerates wound healing, as well as increases plasma levels of KLF4 and wound site myeloid-derived suppressor cell (MDSC) accumulation, in an ob/ob mouse model of diabetic wound healing.{62834}

• Artikelnummer: CAY36773-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36773-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe