Formulation: A solid
Formal Name: N2,N3-bis(4-fluorophenyl)-2,3-quinoxalinediamine
Purity: ≥98%
Formula Markup: C20H14F2N4
Formula Weight: 348,4
Shelf life (days): 1460
CAS Number: 195822-23-2
Notes: LQZ-7I is an inhibitor of survivin.{66066} It inhibits survivin dimerization in a secreted alkaline phosphatase (SEAP) assay using DU145 prostate cancer cells expressing survivin and induces survivin degradation in C4-2 and PC3 prostate cancer cells in a proteasome-dependent manner. LQZ-7I is cytotoxic to C4-2 and PC3 cells (IC50s = 3.1 and 4.8 µM, respectively). It reduces tumor growth in a PC3 mouse xenograft model when administered at a dose of 100 mg/kg.