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M344 , CAS 251456-60-7
M344 , CAS 251456-60-7
Artikelnummer
BPS27203
Verpackungseinheit
5 mg
Hersteller
BPS Bioscience
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Biological Activity: M344 inhibits human HDAC6 with an IC50 of ~14 nM and HDAC1 at ~46 nM.
CAS Number: 251456-60-7
Description: M344 is a histone deacetylase (HDAC) inhibitor also known as D237 or MS 344. It inhibits human HDACs, and shows a three-fold selectivity for inhibition of HDAC6 over HDAC1. M344 has been found to increase the sensitivity of human squamous carcinoma cells to radiation. It has also been found to promote cell cycle arrest and apoptosis in human ovarian cancer cells and endometrial cancer. M344 can also inhibit maize HDAC.
Format: A crystalline solid
Purity: ≥98% by HPLC.
Solubility: Soluble in ethanol is ~3 mg/ml and ~25 mg/ml in DMSO and DMF. For biologicalexperiments, dilute the organic solvent into aqueous buffers or isotonic saline.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Jung, M., et al., J. Med. Chem. 1999; 42: 4669-4679.
2. Remiszewski, S., et al., J. Med. Chem. 2002; 45(4): 753-757.
3. Heltweg, B., et al., J. Med. Chem. 2004.; 47: 5235-5243.
Biological Activity: M344 inhibits human HDAC6 with an IC50 of ~14 nM and HDAC1 at ~46 nM.
CAS Number: 251456-60-7
Description: M344 is a histone deacetylase (HDAC) inhibitor also known as D237 or MS 344. It inhibits human HDACs, and shows a three-fold selectivity for inhibition of HDAC6 over HDAC1. M344 has been found to increase the sensitivity of human squamous carcinoma cells to radiation. It has also been found to promote cell cycle arrest and apoptosis in human ovarian cancer cells and endometrial cancer. M344 can also inhibit maize HDAC.
Format: A crystalline solid
Purity: ≥98% by HPLC.
Solubility: Soluble in ethanol is ~3 mg/ml and ~25 mg/ml in DMSO and DMF. For biologicalexperiments, dilute the organic solvent into aqueous buffers or isotonic saline.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Jung, M., et al., J. Med. Chem. 1999; 42: 4669-4679.
2. Remiszewski, S., et al., J. Med. Chem. 2002; 45(4): 753-757.
3. Heltweg, B., et al., J. Med. Chem. 2004.; 47: 5235-5243.
| Artikelnummer | BPS27203 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 27203 |
| Green Labware | Nein |
| Verpackungseinheit | 5 mg |
| Mengeneinheit | STK |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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Gernot Ensinger, M.Sc.
Laurent Haze
