McMMAF (GMP), CAS 863971-19-1

Product Description: McMMAF GMP is a GMP grade McMMAF (HY-15578). McMMAF is a protective group (maleimidocaproyl)-conjugated MMAF, which is a potent tubulin polymerization inhibitor. McMMAF can be used as a agent-linker for antibody-drug conjugates (ADC). McMMAF is uncleavable, and must be internalized and degraded within a cell, releasing cysteine-McMMAF as the active agent[1][2].

Applications: Cancer-programmed cell death

Formula: C49H76N6O11

References: [1]Polson AG, et al. Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection. Cancer Res. 2009 Mar 15;69(6):2358-2364./[2]Jianmin Fang, et al. Anti-her2 antibody and conjugate thereof. US 20160304621 A1.

CAS Number: 863971-19-1

Molecular Weight: 925.16

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Drug-Linker Conjugates for ADC

• Artikelnummer: MEXHY-15578G-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15578G-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK