Melagatran, CAS 159776-70-2

Formulation: A solid

Formal Name: N-[(1R)-2-[(2S)-2-[[[[4-(aminoiminomethyl)phenyl]methyl]amino]carbonyl]-1-azetidinyl]-1-cyclohexyl-2-oxoethyl]-glycine

Purity: ≥90%

Formula Markup: C22H31N5O4

Formula Weight: 429,5

Shelf life (days): 1460

CAS Number: 159776-70-2

Notes: Melagatran is an inhibitor of thrombin (Ki = 0.002 µM) and an active metabolite of the prodrug ximelagatran (Item No. 16862).{67387} It is selective for thrombin over a variety of serine proteases (Kis = 0.6-10.2 µM) but also inhibits trypsin (Ki = 0.004 µM). Melagatran inhibits thrombin-induced aggregation of isolated washed human platelets (IC50 = 1.9 nM). It decreases the dry weight of thrombi in rats (ED50 = 16 µg/kg).{67388} Melagatran increases total bleeding time and blood loss in rats (ID50s = 300 and 6.8 µg/kg, respectively).{67389} Melagatran (5 µmol/kg per hour), alone or in combination with tissue plasminogen activator (tPA), reduces brain infarct volume and increases blood reperfusion in a rat model of ischemia-induced traumatic brain injury (TBI).{67390}

• Artikelnummer: CAY9002300-2
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9002300-2
• Green Labware: Nein
• Verpackungseinheit: 2 mg
• Mengeneinheit: STK