MMAF (GMP), CAS 745017-94-1

Product Description: MMAF (Monomethylauristatin F) GMP is a GMP grade MMAF (HY-15579). MMAF (Monomethylauristatin F) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A[1][2][3].

Applications: Cancer-programmed cell death

Formula: C39H65N5O8

References: [1]Doronina SO, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24./[2]Lee JW, et al. EphA2 targeted chemotherapy using an antibody drug conjugate in endometrial carcinoma. Clin Cancer Res. 2010 May 1;16(9):2562-70./[3]Lee JJ, et al. Enzymatic prenylation and oxime ligation for the synthesis of stable and homogeneous protein-drug conjugates for targeted therapy. Angew Chem Int Ed Engl. 2015 Oct 5;54(41):12020-4./[4]Kim EG, et al. Strategies and Advancement in Antibody-Drug Conjugate Optimization for Targeted CancerTherapeutics.

CAS Number: 745017-94-1

Molecular Weight: 731.96

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: ADC Cytotoxin;Microtubule/Tubulin

• Artikelnummer: MEXHY-15579G-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15579G-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK