Mogrol, CAS 88930-15-8

Formulation: A solid

Formal Name: (10α)-9β-methyl-19-norlanost-5-ene-3β,11α,24R,25-tetrol

Purity: ≥98%

Formula Markup: C30H52O4

Formula Weight: 476,7

Shelf life (days): 1460

CAS Number: 88930-15-8

Notes: Mogrol is an aglycone form of various mogrosides that has been found in S. grosvenorii and has diverse biological activities.{65829,65830,65831} It inhibits the proliferation and migration of A549, H1299, H1975, and SK-MES-1 lung cancer cells when used at concentrations ranging from 10 to 50 µM.{65829} Mogrol (50 µM) induces AMPK activation and autophagy, as well as apoptosis and cell cycle arrest at the G1 phase in A549 cells. In vivo, mogrol (10 mg/kg) reduces tumor weight and volume in an A549 mouse xenograft model. Mogrol (5 mg/kg) reduces colonic inflammatory cell infiltration and colonic shortening in a mouse model of ulcerative colitis induced by dextran sodium sulfate (DSS; Item No. 23250).{65830} It also improves LPS-induced memory impairments and decreases hippocampal and frontal cortex levels of TNF-α, IL-1β, and IL-6 in LPS-challenged mice.{65831}

• Artikelnummer: CAY39253-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39253-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK