Nutlin-3 , CAS 548472-68-0

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Applications: Useful as an MDM2 antagonist, as a p53 activator and as an apoptosis inducer.

CAS Number: 548472-68-0

Description: Cis-imidazoline analog that inhibits the interaction between p53 and its negative regulator MDM2 (IC50 = 0.09 µM). It induces the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53. Nutlin-3 also inhibits the growth of human tumor xenografts in nude mice by 90% at a dose of 200 mg/kg.

Format: White crystalline solid

Purity: >98% by TLC.

Solubility: Soluble in DMSO (50 mg/ml)

Warnings: Protect from light. Protect from moisture. Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: 1. Vassilev L.T. et al. In vivo activation of the p53 pathway by small -molecule antagonists of MDM2. Science 2004. 303(5659):844.

• Artikelnummer: BPS27711
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 27711
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK