NVP-AEW541, CAS 475489-16-8

Formulation: A solid

Formal Name: 7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Purity: ≥95%

Formula Markup: C27H29N5O

Formula Weight: 439,6

Shelf life (days): 1460

CAS Number: 475489-16-8

Notes: NVP-AEW541 is an inhibitor of insulin-like growth factor 1 receptor (IGF-1R; IC50 = 0.15 µM in a cell-free assay).{17821} It is selective for IGF-1R over a panel of 20 kinases but also inhibits the insulin receptor (InsR), VEGFR1, FMS-related tyrosine kinase 3 (FLT3), and tunica interna endothelial cell kinase 2 (Tie2; IC50s = 0.14, 0.6, 0.42, and 0.53 µM, respectively, in cell-free assays). NVP-AEW541 selectively inhibits the autophosphorylation of IGF-1R over InsR, EGFR, PDGFR, c-Kit, and Bcr-Abl in cells (IC50s = 0.086, 2.3, >10, >10, >5, and >10 µM, respectively). It reduces tumor volume in an NWT-21 murine fibrosarcoma model when administered at doses of 20, 30, or 50 mg/kg twice per day.

• Artikelnummer: CAY33946-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 33946-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK
• Methode: Reinstoffe