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OTX-015, CAS 202590-98-5
OTX-015, CAS 202590-98-5
Artikelnummer
BPS27636-2
Verpackungseinheit
10 mg
Hersteller
BPS Bioscience
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Background: Bromodomains have an important role in the targeting of chromatin-modifying enzymes to specific sites, including methyltransferases, HATs and transcription factors and regulate diverse biological processes from cell proliferation and differentiation to energy homeostasis and neurological processes.
Biological Activity: OTX-015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4. IC50 Value: 0.192 uM (DLBCL cell lines). In vitro, OTX-015 demonstrated anti-proliferative activity in DLBCL cell lines (median IC50 0.192 µM). Similar results were obtained on SMZL (median IC50 0.165 µM), and on MM cell lines (median IC50 0.449 µM). MCL cell lines appeared less sensitive to OTX-015 (median IC50 2.01 µM). Among DLBCL cell lines, there was no difference based upon the cell of origin of the cell lines.
CAS Number: 202590-98-5
Description: OTX-015 is a potent new BRD-inhibitor with evident anti-proliferative activity in several cell lines representative of mature B-cell tumors.
Purity: ≥98% by HPLC
Solubility: Soluble in DMSO
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Noel, J.K., et al. Mol. Cancer Ther. 12 , C244 (2013).
2. Braun, T., et al. Blood 122, 4218 (2014).
Background: Bromodomains have an important role in the targeting of chromatin-modifying enzymes to specific sites, including methyltransferases, HATs and transcription factors and regulate diverse biological processes from cell proliferation and differentiation to energy homeostasis and neurological processes.
Biological Activity: OTX-015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4. IC50 Value: 0.192 uM (DLBCL cell lines). In vitro, OTX-015 demonstrated anti-proliferative activity in DLBCL cell lines (median IC50 0.192 µM). Similar results were obtained on SMZL (median IC50 0.165 µM), and on MM cell lines (median IC50 0.449 µM). MCL cell lines appeared less sensitive to OTX-015 (median IC50 2.01 µM). Among DLBCL cell lines, there was no difference based upon the cell of origin of the cell lines.
CAS Number: 202590-98-5
Description: OTX-015 is a potent new BRD-inhibitor with evident anti-proliferative activity in several cell lines representative of mature B-cell tumors.
Purity: ≥98% by HPLC
Solubility: Soluble in DMSO
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Noel, J.K., et al. Mol. Cancer Ther. 12 , C244 (2013).
2. Braun, T., et al. Blood 122, 4218 (2014).
| Artikelnummer | BPS27636-2 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 27636-2 |
| Green Labware | Nein |
| Verpackungseinheit | 10 mg |
| Mengeneinheit | STK |
| Produktinformation (PDF) |
|
| MSDS (PDF) |
|
Immer für Sie da
Gernot Ensinger, M.Sc.
Laurent Haze
