P005091 , CAS 882257-11-6

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Background: USP7, known as herpes-associated-ubiquitin-specificprotease (HAUSP), is a deubiquitylating enzyme that regulates the levels of the oncoprotein HDM2 and its substrate, the tumor suppressor p53. P005091 accelerated the degradation of HDM2, while analogs of the compound induced dose- and time-dependent increases in the protein levels of p53 and p21. P005091 induced apoptosis in numerous cancer cell lines, including both p53+/+ and p53-mutant cancer cell lines. P005091 also downregulated claspin and phosphorylation of the DNA checkpoint kinase Chk1.

Biological Activity: Selective inhibitor of ubiquitin-specific protease (USP) 7 (IC50 = 4.2 µM). Displays little-to-no inhibition of other USP variants or proteases such as caspase, cathepsins and serine proteases; exhibits some activity on USP47. Induces elevated p53 and apoptosis in cancer cell lines; displays antiangiogenic activity in vivo.

CAS Number: 882257-11-6

Description: P005091 is a selective, potent inhibitor of USP7 deubiquitylating activity.

Solubility: Soluble in DMSO

Storage Stability: Store at or below +4°C. Solid form is stable at least 12 months from date of receipt, when stored as directed.

Target: USP7

Biosafety Level: Not applicable (BSL-1)

• Artikelnummer: BPS27767-2
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 27767-2
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK