P110 (trifluoroacetate salt)

Formulation: A solid

Formal Name: (3S,12S,15S,18S,21S,24S,27S,30S,33S,36S,42S)-42-amino-3-(((S)-1-(((S)-1-((S)-2-(((S)-1-((2-(((S)-1-amino-3-hydroxy-1-oxopropan-2-yl)amino)-2-oxoethyl)amino)-5-guanidino-1-oxopentan-2-yl)carbamoyl)pyrrolidin-1-yl)-4-methyl-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)-21-(3-amino-3-oxopropyl)-30,33-bis(4-aminobutyl)-12,15,18,24,27,36-hexakis(3-guanidinopropyl)-43-(4-hydroxyphenyl)-5,8,11,14,17,20,23,26,29,32,35,38,41-tridecaoxo-4,7,10,13,16,19,22,25,28,31,34,37,40-tridecaazatritetracontanoic acid, trifluoroacetate salt

Purity: ≥95%

Formula Markup: C100H179N45O25 • XCF3COOH

Formula Weight: 2411,8

Shelf life (days): 1460

Notes: P110 is a peptide inhibitor of the mitochondrial GTPase dynamin-related protein 1 (DRP1).{66508} It selectively inhibits DRP1 GTPase activity over the additional mitochondrial GTPases OPA1, MFN1, and dynamin 1 at 1 µM. P110 (1 µM) inhibits the MPP+-induced protein-protein interaction between DRP1 and mitochondrial fission 1 (FIS1), as well as MPP+-, carbonyl cyanide M-chloro phenyl hydrazone-, rotenone-, or hydrogen peroxide-induced DRP1 translocation to the mitochondria in SH-SY5Y cells. It also inhibits MPP+-induced mitochondrial apoptosis and autophagy in SH-SY5Y cells and MPP+-induced mitochondrial fragmentation and cell death in a primary rat dopaminergic neuronal model of Parkinson’s disease.

• Artikelnummer: CAY37450-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37450-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK