PF-04691502, CAS 1013101-36-4

Formulation: A crystalline solid

Formal Name: 2-amino-8-[trans-4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxy-3-pyridinyl)-4-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one

Purity: ≥95%

Formula Markup: C22H27N5O4

Formula Weight: 425,5

Shelf life (days): 1460

CAS Number: 1013101-36-4

Notes: PF-04691502 is an inhibitor of PI3Kα, -β, -δ, and -γ and mammalian target of rapamycin (mTOR; Kis = 1.8, 2.1, 1.6, 1.9, and 16 nM, respectively, for the human enzymes).{22526} It decreases the proliferation of BT-20 breast cancer, SKOV3 ovarian cancer, and U87MG glioblastoma cells (IC50s = 313, 188, and 179 nM, respectively). PF-04691502 (2.5 and 5 µM) inhibits capillary tube formation by, and migration of, human umbilical vein endothelial cells (HUVECs).{69429} It induces cell cycle arrest at the G1 phase in U87MG cells when used at concentrations of 500 and 1,000 nM.{22526} PF-04691502 (10 mg/kg per day) decreases tumor volume in NCI H1650 and H1975 non-small cell lung cancer (NSCLC) mouse xenograft models.

• Artikelnummer: CAY15017-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 15017-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK