PF-04753299, CAS 1289620-49-0

Formulation: A solid

Formal Name: N-hydroxy-αR-methyl-α-(methylsulfonyl)-[1,1′-biphenyl]-4-butanamide

Purity: ≥98%

Formula Markup: C18H21NO4S

Formula Weight: 347,4

Shelf life (days): 1460

CAS Number: 1289620-49-0

Notes: PF-04753299 is an inhibitor of LpxC (IC50 = 1.37 nM), a bacterial deacetylase involved in the biosynthesis of LPS lipid A.{58957} It is selective for LpxC over a panel of 16 human matrix metalloproteinases (MMPs; Kis = >1 µM for all). PF-04753299 is active against P. aeruginosa, K. pneumoniae, E. coli, E. aerogenes, C. freundii, and A. baumannii (MIC90s = 4, 16, 2, 4, 8, and 32 µg/ml, respectively). In vivo, PF-04753299 reduces splenic bacterial burden in a mouse model of systemic P. aeruginosa infection (ED50 = 35 mg/kg).

• Artikelnummer: CAY36502-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36502-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe