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CAS Number: 371935-74-9
Description: PI-103 is a multi-targeted inhibitor of PI3K for p110, p110, p110 , and p110with reported IC50 values of 2 nM, 3 nM, 3 nM, and 15 nM respectively. PI-103 is less potenttowards mTOR/DNA-PK with reported IC50 values of 30 nM and 23 nM respectively.
Format: Crystalline solid
Purity: ≥98%
Solubility: Soluble in DMSO or DMF at approximately 10 mg/ml. Poorly soluble in aqueoussolutions. If necessary, first solubilize in DMSO or DMF and dilute into an aqueous solution,such as PBS.
Storage Stability: At least 2 years as supplied at -20°C. At least 6 months in DMSO at -80°C.Do not store aqueous solutions for longer than one day.
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Zou, Z.Q., et al., Int. J. Mol. Med. 2009; 24(1): 97-101.
2. Lopez-Fauqued, M. et al., Int. J. Canc. 2010; 126(7): 1549-1561.