PK68, CAS 2173556-69-7

Formulation: A solid

Formal Name: N-[5-[2-(acetylamino)-6-benzothiazolyl]-2-methyl-3-pyridinyl]-carbamic acid, cyclohexyl ester

Purity: ≥98%

Formula Markup: C22H24N4O3S

Formula Weight: 424,5

Shelf life (days): 1460

CAS Number: 2173556-69-7

Notes: PK68 is an inhibitor of receptor-interacting serine/threonine kinase 1 (RIPK1; IC50 = 90 nM).{66561} It is selective for RIPK1 over RIPK3 and a panel of 369 kinases at 1,000 nM. PK68 inhibits necroptosis induced by TNF-α, a Smac mimetic, and z-VAD in HT-29 colon cancer cells (EC50 = 23 nM). It reduces the number of lung metastases in a B16/F10 murine melanoma model when administered at a dose of 5 mg/kg. PK68 (1 mg/kg) increases survival and prevents decreases in body temperature and increases in serum Il-1β levels in a mouse model of Tnf-α-induced systemic inflammatory response syndrome (SIRS).

• Artikelnummer: CAY36653-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36653-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK