Prostaglandin E2 Inhibitor 3

Formulation: A solid

Formal Name: 2-bromo-N-(5-(3'-hydroxy-[1,1'-biphenyl]-4-yl)-1,3,4-thiadiazol-2-yl)benzamide

Purity: ≥95%

Formula Markup: C21H14BrN3O2S

Formula Weight: 452,3

Shelf life (days): 1095

Notes: Prostaglandin E2 (PGE2) inhibitor 3 is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC50 = 0.2 µM).{51389} It is selective for mPGES-1 over COX-1, COX-2, 5-lipoxygenase (5-LO), and soluble epoxide hydrolase (sEH) in cell-free assays at 10 µM. PGE2 inhibitor 3 inhibits IL-1β-induced production of PGE2 (Item No. 14010) in A549 cells and LPS-induced IL-6 and PGE2 production in J774A.1 macrophages when used at concentrations of 10 and 1 µM, respectively. It also inhibits the formation of 5-LO products, including leukotriene B4 (LTB4; Item No. 20110) and 5-H(p)ETE, induced by the calcium ionophore A23187 (Item Nos. 11016 / 22030) alone or with arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607) and A23187 (IC50s = 4.9 and 5.2 µM, respectively). In vivo, PGE2 inhibitor 3 (10 mg/kg) prevents leukocyte infiltration into the peritoneal fluid in a mouse model of zymosan-induced peritonitis.

• Artikelnummer: CAY38316-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 38316-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK